InterPro : IPR000770

Name  SAND domain Short Name  SAND_dom
Type  Domain Description  The SAND domain (named after Sp100, AIRE-1, NucP41/75, DEAF-1) is a conserved~80 residue region found in a number of nuclear proteins, many of whichfunction in chromatin-dependent transcriptional control. These includeproteins linked to various human diseases, such as the Sp100 (Speckled protein100 kDa), NUDR (Nuclear DEAF-1 related), GMEB (Glucocorticoid ModulatoryElement Binding) proteins and AIRE-1 (Autoimmune regulator 1) proteins.Proteins containing the SAND domain have a modular structure; the SAND domaincan be associated with a number of other modules, including the bromodomain, the PHD finger and the MYND finger.Because no SAND domain has been found in yeast, it is thought that the SANDdomain could be restricted to animal phyla. Many SAND domain-containingproteins, including NUDR, DEAF-1 (Deformed epidermal autoregulatory factor-1)and GMEB, have been shown to bind DNA sequences specifically. The SAND domainhas been proposed to mediate the DNA binding activity of these proteins [, ].The resolution of the 3D structure of the SAND domain from Sp100b has revealedthat it consists of a novel alpha/beta fold. The SAND domainadopts a compact fold consisting of a strongly twisted, five-strandedantiparallel beta-sheet with four alpha-helices packing against one side ofthe beta-sheet. The opposite side of the beta-sheet is solvent exposed. Thebeta-sheet and alpha-helical parts of the structure form two distinct regions.Multiple hydrophobic residues pack between these regions to form a structuralcore. A conserved KDWK sequence motif is found within the alpha-helical,positively charged surface patch. The DNA binding surface has been mapped tothe alpha-helical region encompassing the KDWK motif [].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR008087 Autoimmune regulator, AIRE AIRE Family
IPR020533 Developmental regulator, ULTRAPETALA Developmental_reg_ULTRAPETALA Family

1 Parent Features

Id Name Short Name Type
IPR010919 SAND domain-like SAND_dom-like Domain

2 Publications

First Author Title Year Journal Volume Pages
Gibson TJ The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. 1998 Trends Biochem Sci 23 242-4
Bottomley MJ The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation. 2001 Nat Struct Biol 8 626-33



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)