InterPro : IPR030195

Name  Equilibrative nucleoside transporter 1 Short Name  ENT1
Type  Family Description  Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter ENT1 was the first identified member of the ENT family. ENT1 (also known as solute carrier family 29 member 1, SLC29A1) mediates both influx and efflux of nucleosides across the membrane, including adenosine and many anti-cancer nucleoside drugs [, ]. ENT1 has a predicted topology of 11 transmembrane domains (TMDs) and a large hydrophilic loop in the region between TMD5 and TMD7 []. ENT1 -as ENT2- is localised in plasma membranes and is broadly expressed in tissues [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR002259 Equilibrative nucleoside transporter Eqnu_transpt Family

5 Publications

First Author Title Year Journal Volume Pages
Young JD The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. 2013 Mol Aspects Med 34 529-47
Sundaram M Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs. 2001 J Biol Chem 276 45270-5
Baldwin SA The equilibrative nucleoside transporter family, SLC29. 2004 Pflugers Arch 447 735-43
Griffiths M Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. 1997 Nat Med 3 89-93
Kiss A Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. 2000 Biochem J 352 Pt 2 363-72

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)