InterPro : IPR015497

Name  Epidermal growth factor receptor ligand Short Name  EGF_rcpt_ligand
Type  Family Description  The mammalian ligands that bind the EGF receptor (EGFR) include EGF, transforming growth factor-alpha (TGFalpha), heparin-binding EGF-like growth factor (HB-EGF), amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), and epigen. Each contains one or more copies of the EGF repeat. The EGF domain includes six cysteine residues, which have been shown (in EGF) to be involved in disulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length.Interestingly, this entry also includes some epidermal growth factor-likeproteins secreted from virus, including pro-vaccinia growth factor from Vaccinia virus [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Lin YZ Growth inhibition by vaccinia virus growth factor. 1990 J Biol Chem 265 18884-90

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)