InterPro : IPR014048

Name  Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding Short Name  MethylDNA_cys_MeTrfase_DNA-bd
Type  Domain Description  Synonym(s): 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferaseThis entry represents the DNA binding region of 6-O-methylguanine-DNA methyltransferases.The repair of DNA containing O6-alkylatedguanine is carried out by DNA-[protein]-cysteine S-methyltransferase (). The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. Thealkyl group at the O-6 position is transferred to a cysteine residue in theenzyme []. This is a suicide reaction since the enzyme is irreversibly inactivatedand the methylated protein accumulates as a dead-end product. Most, but notall of the methyltransferases are also able to repair O-4-methylthymine. DNA-[protein]-cysteine S-methyltransferases are widely distributed and are found in various prokaryotic and eukaryotic sources [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site MethylDNA_cys_MeTrfase_AS Active_site

1 Found In

Id Name Short Name Type
IPR016221 Bifunctional regulatory protein Ada Bifunct_regulatory_prot_Ada Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

2 Publications

First Author Title Year Journal Volume Pages
Lindahl T Regulation and expression of the adaptive response to alkylating agents. 1988 Annu Rev Biochem 57 133-57
Rafferty JA Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA. 1992 Nucleic Acids Res 20 1891-5

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)