InterPro : IPR001367

Name  Iron dependent repressor-like, metal binding and dimerisation domain Short Name  Fe_dep_repressor
Type  Domain Description  The diphtheria toxin repressor protein (DTXR) is a member of this group []. In Corynebacterium diphtheriaewhere it has been studied in some detail this protein actsas an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N terminus may be involved in iron binding andmay associate with the Tox operator. Binding of DTXR to Tox operator requires a divalentmetal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

1 Found In

Id Name Short Name Type
IPR022689 Iron dependent repressor, diptheria toxin type Fe_dep_repressor_HTH_DtxR Domain

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Schiering N Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae. 1995 Proc Natl Acad Sci U S A 92 9843-50
Qiu X Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors. 1995 Structure 3 87-100

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)