InterPro : IPR004865

Name  Homogeneously-staining region Short Name  HSR_dom
Type  Domain Description  The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerisation domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) []. This domain can also be found in Vertebrate AutoImmune REgulator (AIRE) protein, a transcription regulator predominantly expressed in thymus medullary epithelial cells which also localises to nuclear dots []. The HSR domain, which has also been named ASS (AIRE, Sp-100 and Sp140) domain [], can be found alone or in association with other domains, such as SAND , PHD finger and Bromo , The HSR domain is predicted to be predominantly alpha-helical [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR008087 Autoimmune regulator, AIRE AIRE Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Gibson TJ The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. 1998 Trends Biochem Sci 23 242-4
Mittaz L Isolation and characterization of the mouse Aire gene. 1999 Biochem Biophys Res Commun 255 483-90
Sternsdorf T The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers. 1999 J Biol Chem 274 12555-66
Perniola R The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein. 2014 Biochim Biophys Acta 1842 326-37

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)