InterPro : IPR011398

Name  Fibrillin/Microneme protein4 Short Name  FBN/EtMIC4
Type  Family Description  This family includes fibrillin-1, 2 and 3. Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support [].This entry also includes microneme protein 4 (EtMIC4) from Eimeria tenella. EtMIC4 is a transmembrane protein that has multiple thrombospondin type I domains and calcium-binding epidermal growth factor-like domains inits extracellular domain []. It forms a complex with EtMIC5 that binds target host cells [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

7 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR009030 Insulin-like growth factor binding protein, N-terminal Growth_fac_rcpt_N_dom Domain
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR017878 TB domain TB_dom Domain
IPR000152 EGF-type aspartate/asparagine hydroxylation site EGF-type_Asp/Asn_hydroxyl_site PTM
IPR018097 EGF-like calcium-binding, conserved site EGF_Ca-bd_CS Conserved_site

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Corson GM Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues. 2004 Genomics 83 461-72
Periz J The microneme proteins EtMIC4 and EtMIC5 of Eimeria tenella form a novel, ultra-high molecular mass protein complex that binds target host cells. 2007 J Biol Chem 282 16891-8
Tomley FM EtMIC4: a microneme protein from Eimeria tenella that contains tandem arrays of epidermal growth factor-like repeats and thrombospondin type-I repeats. 2001 Int J Parasitol 31 1303-10



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)