InterPro : IPR017304

Name  Cytoplasmic protein NCK Short Name  NCK
Type  Family Description  Cytoplasmic protein NCK (NCK) is a family of non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain []. They associate with tyrosine-phosphorylated growth factor receptors or their cellular substrates [,]. They are implicated in organisation of actin cytoskeleton, cell movement or axon guidance []. There are two vertebrate NCK proteins, NCK1 and NCK2.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR028524 Cytoplasmic protein NCK2 NCK2 Family
IPR028526 Cytoplasmic protein NCK1 NCK1 Family

2 Contains

Id Name Short Name Type
IPR001452 SH3 domain SH3_domain Domain
IPR000980 SH2 domain SH2 Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Matuoka K A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. 1997 Biochem Biophys Res Commun 239 488-92
Tu Y Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. 2001 FEBS Lett 491 193-9
Round JE The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology. 2011 Mol Cell Neurosci 47 265-73
Buday L The Nck family of adapter proteins: regulators of actin cytoskeleton. 2002 Cell Signal 14 723-31

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)