InterPro : IPR028762

Name  Ski family transcriptional corepressor 1 Short Name  SKOR1
Type  Family Description  Ski family transcriptional corepressor 1 (SKOR1), also known as ladybird homeobox corepressor 1 or fussel-15 homologue, belongs to Ski family. Like the other members, it is characterised by a Ski homologue domain and a SAND domain - a domain found in some nuclear proteins involved in chromatin-dependent transcriptional regulation. Fussel-15 is mainly expressed in the central nervous system (CNS). The Ski family of nuclear oncoproteins is known to represses transforming growth factor-beta (TGF-beta) signalling through inhibition of transcriptional activity of Smad proteins. Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signalling pathway, but it has only minor effects on TGF-beta signalling [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR023216 Transcription regulator SKI/SnoN Tscrpt_reg_SKI_SnoN Family

1 Publications

First Author Title Year Journal Volume Pages
Arndt S Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. 2007 Mol Cell Neurosci 34 603-11

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)