InterPro : IPR000601

Name  PKD domain Short Name  PKD_dom
Type  Domain Description  The PKD (Polycystic Kidney Disease) domain was first identified in the Polycystic Kidney Disease protein, polycystin-1 (PDK1 gene), and contains an Ig-like fold consisting of a beta-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands []. Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein-protein and protein-carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions. PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal surface layer proteins that protect the cell from extreme environments [], and in the human VPS10 domain-containing receptor SorCS2 [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR002859 PKD/REJ-like protein PKD/REJ-like Domain
IPR002169 Peptidase M9A/M9B, collagenase, bacterial Peptidase_M9A/M9B Family
IPR006228 Polycystin cation channel Polycystin_cat Domain
IPR017323 Lysyl endopeptidase Lysyl_endo-pept Family

1 Parent Features

Id Name Short Name Type
IPR022409 PKD/Chitinase domain PKD/Chitinase_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Bycroft M The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. 1999 EMBO J 18 297-305
Jing H Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. 2002 Structure 10 1453-64
Hampe W The genes for the human VPS10 domain-containing receptors are large and contain many small exons. 2001 Hum Genet 108 529-36

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)