InterPro : IPR022675

Name  Glucose-6-phosphate dehydrogenase, C-terminal Short Name  G6P_DH_C
Type  Domain Description  Glucose-6-phosphate dehydrogenase () (G6PDH) is a ubiquitous protein, presentin bacteria and all eukaryotic cell types []. The enzyme catalyses thethe first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells []. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [].This entry represents the C-terminal domain of glucose-6-phosphate dehydrogenase.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR001282 Glucose-6-phosphate dehydrogenase G6P_DH Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Fouts D Nucleotide sequence of the Drosophila glucose-6-phosphate dehydrogenase gene and comparison with the homologous human gene. 1988 Gene 63 261-75
Vulliamy TJ Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia. 1988 Proc Natl Acad Sci U S A 85 5171-5



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)