InterPro : IPR017072

Name  Transcription elongation factor Spt6 Short Name  TF_Spt6
Type  Family Description  This family consists of several eukaryotic nuclear transcription elongation proteins characterised by an extremely acidic N-terminal region. In yeast, increased or decreased dosage of Spt6 protein can change gene expression []. In addition, all members contain a YqgFc domain. This domain is found primarily in low-GC Gram-positive bacteria Holliday junction resolvases. However, in Spt6 orthologues, the catalytic residues are substituted, indicating that they lack resolvase activity. Some members contain a copy of the S1 domain () that occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein, which binds nucleic acids. The S1 domain has an OB-fold structure. Adjacent to this domain one to two copies of the SH2 domain are present () which are regulatory modules of signal cascades.Three transcription-elongation factors--Spt4, Spt5, and Spt6--are conserved among eukaryotes and are essential for transcription via modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans, including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR000980 SH2 domain SH2 Domain
IPR003029 Ribosomal protein S1, RNA-binding domain Rbsml_prot_S1_RNA-bd_dom Domain
IPR006641 YqgF/RNase H-like domain YqgF/RNaseH-like_dom Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Winston F Control of eukaryotic transcription elongation. 2001 Genome Biol 2 REVIEWS1006
Chiang PW Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. 1996 Genomics 34 328-33

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)