InterPro : IPR005913

Name  dTDP-4-dehydrorhamnose reductase family Short Name  dTDP_dehydrorham_reduct
Type  Family Description  dTDP-4-dehydrorhamnose reductase () catalyses the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose, which is the final step in the conversion of dTDP-D-glucose to dTDP-L-rhamnose []. dTDP-rhamnose is essential for growth of mycobacteria []. dTDP-L-rhamnose is the precursor of L-Rhamnose (L-Rha), a component of the lipopolysaccharide (LPS) core and several O antigen polysaccharides of Pseudomonas [].Methionine adenosyltransferase 2 subunit beta (MAT2B) also belongs to this family. It is the regulatory subunit of MAT2A, an enzyme that catalyses the formation of S-adenosylmethionine (AdoMet) from methionine and ATP [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR029898 Methionine adenosyltransferase 2 subunit beta MAT2_B Family
IPR029900 dTDP-4-dehydrorhamnose reductase RmlD Family

1 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Yoo HG A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis. 2011 Bioorg Med Chem Lett 21 3914-7
Ma Y Formation of dTDP-rhamnose is essential for growth of mycobacteria. 2002 J Bacteriol 184 3392-5
Rahim R Involvement of the rml locus in core oligosaccharide and O polysaccharide assembly in Pseudomonas aeruginosa. 2000 Microbiology 146 ( Pt 11) 2803-14
LeGros HL Jr Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). 2000 J Biol Chem 275 2359-66

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)