InterPro : IPR003121

Name  SWIB/MDM2 domain Short Name  SWIB_MDM2_domain
Type  Domain Description  The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation []. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. BAF60b is present in alternative forms of the SWI/SNF complex, including complex B (SWIB), which lacks BAF60a. The SWIB domain is a conserved region found within the BAF60b proteins [], and can be found fused to the C terminus of DNA topoisomerase in Chlamydia.MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. p53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. The core of MDM2 folds into an open bundle of four helices, which is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain.The SWIB and MDM2 domains are homologous and sharea common fold.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR019835 SWIB domain SWIB_domain Domain

0 Contains

3 Found In

Id Name Short Name Type
IPR015459 Ubiquitin-protein ligase E3 MDM2 MDM2_E3_ligase Family
IPR016495 p53 negative regulator Mdm2/Mdm4 p53_neg-reg_MDM_2/4 Family
IPR015458 MDM4 MDM4 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Kussie PH Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. 1996 Science 274 948-53
Decristofaro MF Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. 2001 J Cell Physiol 186 136-45
Bennett-Lovsey R The SWIB and the MDM2 domains are homologous and share a common fold. 2002 Bioinformatics 18 626-30

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)