InterPro : IPR003121

Name  SWIB/MDM2 domain Short Name  SWIB_MDM2_domain
Type  Domain Description  The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation []. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. BAF60b is present in alternative forms of the SWI/SNF complex, including complex B (SWIB), which lacks BAF60a. The SWIB domain is a conserved region found within the BAF60b proteins [], and can be found fused to the C terminus of DNA topoisomerase in Chlamydia.MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. p53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. The core of MDM2 folds into an open bundle of four helices, which is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain.The SWIB and MDM2 domains are homologous and sharea common fold.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR019835 SWIB domain SWIB_domain Domain

0 Contains

3 Found In

Id Name Short Name Type
IPR015459 Ubiquitin-protein ligase E3 MDM2 MDM2_E3_ligase Family
IPR016495 p53 negative regulator Mdm2/Mdm4 p53_neg-reg_MDM_2/4 Family
IPR015458 MDM4 MDM4 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Kussie PH Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. 1996 Science 274 948-53
Decristofaro MF Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. 2001 J Cell Physiol 186 136-45
Bennett-Lovsey R The SWIB and the MDM2 domains are homologous and share a common fold. 2002 Bioinformatics 18 626-30



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)