InterPro : IPR012599

Name  Peptidase C1A, propeptide Short Name  Propeptide_C1A
Type  Domain Description  This domain is found at the N-terminal of cathepsin B and cathepsin B-like peptidases that belong to MEROPS peptidase subfamily C1A. Cathepsin B are lysosomal cysteine proteinases belonging to the papain superfamily and are unique in their ability to act as both an endo- and an exopeptidases. They are synthesized as inactive zymogens. Activation of the peptidases occurs with the removal of the propeptide [, ].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR013128 Peptidase C1A Peptidase_C1A Family
IPR015643 Peptidase C1A, cathepsin B Peptidase_C1A_cathepsin-B Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Jia Z Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. 1995 J Biol Chem 270 5527-33
Cygler M Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. 1996 Structure 4 405-16



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)