InterPro : IPR029540

Name  Calpain-6 Short Name  CAPN6
Type  Family Description  Calpain-6 (CAPN6) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. However, CAPN6 lacks the active-site cysteine residues, suggesting a loss of proteolytic activity. It is involved in regulating microtubule dynamics and actin reorganisation [, ]. CAPN6 may function as a suppressor of skeletal muscle differentiation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR022684 Peptidase C2, calpain family Calpain_cysteine_protease Family

4 Publications

First Author Title Year Journal Volume Pages
Goll DE The calpain system. 2003 Physiol Rev 83 731-801
Jeong SY Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. 2013 Proc Natl Acad Sci U S A 110 E4007-15
Tonami K Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. 2007 Mol Cell Biol 27 2548-61
Tonami K Calpain-6 deficiency promotes skeletal muscle development and regeneration. 2013 PLoS Genet 9 e1003668

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)