InterPro : IPR030217

Name  Nuclear RNA export factor Short Name  NXF_fam
Type  Family Description  Mex67 is involved in the export of mRNA from the nucleus to the cytoplasm in Saccharomyces cerevisiae []. Vertebrate TAP (also called NXF1 for nuclear RNA export factor 1) is the orthologue of Mex67 []. TAP belongs to a multigene family with conserved modular architecture []. Other members of the family in humans are NXF2, NXF3, and NFX5. Both TAP(NXF1) and NXF2 bind mRNA and display RNA nuclear export activity []. NXF3 also has the ability to export mRNA from the nucleus to the cytoplasm but it uses a different mechanism []. NXF1 and NXF2 are predominantly nuclear, whereas the cytoplasmic presence of NXF3 and NXF5 suggests that they have a different cellular function [, ].Three functional domains of TAP have been characterised: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain. The RNA-binding domain (RBD) of TAP is located at its amino terminus and is composed of two RNA recognition motifs (RRMs) and one leucine-rich region [, ]. Once bound to mRNA, TAP escorts the messenger ribonucleoprotein (mRNP) to the nuclear pore, where TAP interacts with nucleoporins via the NTF2-like (NTF2L) and UBA domains [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR030216 Nuclear RNA export factor 3 NXF3 Family
IPR030218 Nuclear RNA export factor 5 NXF5 Family

0 Contains

0 Found In

0 Parent Features

9 Publications

First Author Title Year Journal Volume Pages
Herold A TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. 2000 Mol Cell Biol 20 8996-9008
Yang J Two closely related human nuclear export factors utilize entirely distinct export pathways. 2001 Mol Cell 8 397-406
Fribourg S Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. 2001 Mol Cell 8 645-56
Grüter P TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. 1998 Mol Cell 1 649-59
Segref A Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. 1997 EMBO J 16 3256-71
Jun L NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. 2001 Curr Biol 11 1381-91
Zolotukhin AS U2AF participates in the binding of TAP (NXF1) to mRNA. 2002 J Biol Chem 277 3935-42
Hautbergue GM Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP. 2008 Proc Natl Acad Sci U S A 105 5154-9
Bachi A The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. 2000 RNA 6 136-58

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)