InterPro : IPR011364

Name  Breast cancer type 1 susceptibility protein (BRCA1) Short Name  BRCA1
Type  Family Description  Breast cancer is a common malignancy, affecting 1 in 8 women. A major contributary factor in disease development lies in a positive family history, a correlation that is striking for early-onset breast cancer. Mutations in the DNA-damage repair protein BRCA1 [,]are believed to be responsible for 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer.The BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [, ]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

4 Contains

Id Name Short Name Type
IPR001841 Zinc finger, RING-type Znf_RING Domain
IPR018957 Zinc finger, C3HC4 RING-type Znf_C3HC4_RING-type Domain
IPR001357 BRCT domain BRCT_dom Domain
IPR017907 Zinc finger, RING-type, conserved site Znf_RING_CS Conserved_site

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Yu X The BRCT domain is a phospho-protein binding domain. 2003 Science 302 639-42
Xu X Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. 1999 Mol Cell 3 389-95
Khavari PA BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. 1993 Nature 366 170-4
Lorick KL RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. 1999 Proc Natl Acad Sci U S A 96 11364-9
Lee JS hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. 2000 Nature 404 201-4



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)