InterPro : IPR003316

Name  E2F/DP family, winged-helix DNA-binding domain Short Name  E2F_WHTH_DNA-bd_dom
Type  Domain Description  This entry represents the DNA-binding domain of the E2F and DP proteins, which have a fold related to the winged-helix DNA-binding motif []. The mammalian transcription factor E2F plays an important role in regulating theexpression of genes that are required for passage through the cell cycle. Multiple E2F family members have been identified that bind to DNA as heterodimers, interacting with proteins known as DP - the dimerisation partners [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR015633 E2F Family E2F Family
IPR015648 Transcription factor DP Transcrpt_fac_DP Family
IPR015635 Transcription factor E2F6 Transcription_factor_E2F6 Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

2 Publications

First Author Title Year Journal Volume Pages
Wu CL In vivo association of E2F and DP family proteins. 1995 Mol Cell Biol 15 2536-46
Zheng N Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. 1999 Genes Dev 13 666-74

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)