InterPro : IPR001732

Name  UDP-glucose/GDP-mannose dehydrogenase, N-terminal Short Name  UDP-Glc/GDP-Man_DH_N
Type  Domain Description  The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate [, ].The enzymes have a wide range of functions. In plants UDP-glucose dehydrogenase, , is an important enzyme in the synthesis of hemicellulose and pectin [], which are the components of newly formed cell walls; while in zebrafish UDP-glucose dehydrogenase is required for cardiac valve formation []. In Xanthomonas campestris, a plant pathogen, UDP-glucose dehydrogenase is required for virulence []. GDP-mannose dehydrogenase, , catalyses the formation of GDP-mannuronic acid, which is the monomeric unit from which the exopolysaccharide alginate is formed. Alginate is secreted by a number of bacteria, which include Pseudomonas aeruginosaand Azotobacter vinelandii. In P. aeruginosa, alginate is believed to play an important role in the bacteria's resistance to antibiotics and the host immune response [], while in A. vinelandii it is essential for the encystment process [].This entry represents the N-terminal NAD(+)-binding domain. Structural studies indicate that this domain forms an alpha-beta structure containing the six-stranded parallel beta sheet characteristic of the dinucleotide binding Rossman fold [, ].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR017476 UDP-glucose/GDP-mannose dehydrogenase UDP-Glc/GDP-Man Family

1 Parent Features

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain

9 Publications

First Author Title Year Journal Volume Pages
Roychoudhury S Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa. 1989 J Biol Chem 264 9380-5
Campbell RE Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetol. 1997 J Biol Chem 272 3416-22
Johansson H Molecular cloning and characterization of a cDNA encoding poplar UDP-glucose dehydrogenase, a key gene of hemicellulose/pectin formation. 2002 Biochim Biophys Acta 1576 53-8
Walsh EC UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. 2001 Science 293 1670-3
Chang KW UDP-glucose dehydrogenase gene of Xanthomonas campestris is required for virulence. 2001 Biochem Biophys Res Commun 287 550-5
Naught LE Allosterism and cooperativity in Pseudomonas aeruginosa GDP-mannose dehydrogenase. 2002 Biochemistry 41 9637-45
Núñez C The Azotobacter vinelandii response regulator AlgR is essential for cyst formation. 1999 J Bacteriol 181 141-8
Snook CF Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa. 2003 Biochemistry 42 4658-68
Campbell RE The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation. 2000 Biochemistry 39 7012-23



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)