InterPro : IPR000705

Name  Galactokinase Short Name  Galactokinase
Type  Family Description  Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [, ].Deficiency in this enzyme results in the disease galactosemia, which is responsible for theformation of cataracts in newborn babies, and is possibly responsible for presenile cataracts inadults []. In yeast, the GAL3 gene product is required for the GAL4-mediated inductionof other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforcesthis process, increasing the expression of other galactose-inducible genes. GAL3 has been shown tobe similar to the GAL1 protein [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR022963 Galactokinase, bacterial Galactokinase_bac Family

7 Contains

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR013750 GHMP kinase, C-terminal domain GHMP_kinase_C_dom Domain
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR019539 Galactokinase galactose-binding domain GalKase_gal-bd Domain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain
IPR019741 Galactokinase, conserved site Galactokinase_CS Conserved_site
IPR006203 GHMP kinase, ATP-binding, conserved site GHMP_knse_ATP-bd_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR006206 Mevalonate/galactokinase Mevalonate/galactokinase Family

2 Publications

First Author Title Year Journal Volume Pages
Bajwa W Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases. 1988 Mol Cell Biol 8 3439-47
Lee RT Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast. 1992 Proc Natl Acad Sci U S A 89 10887-91



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)