InterPro : IPR006204

Name  GHMP kinase N-terminal domain Short Name  GHMP_kinase_N_dom
Type  Domain Description  The galacto- (), homoserine (), mevalonate () and phosphomevalonate () kinases contain, in their N-terminal section, a conserved domain with a Gly/Ser-rich region which is probably involved in the binding of ATP [, ]. This group of kinases has been called 'GHMP' (from the first letter of their substrates).This domain is also found in diphosphomevalonate decarboxylases, which are structurally related members of the GHMP superfamily [], but do not possess kinase activity.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR006203 GHMP kinase, ATP-binding, conserved site GHMP_knse_ATP-bd_CS Conserved_site

18 Found In

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR006206 Mevalonate/galactokinase Mevalonate/galactokinase Family
IPR000705 Galactokinase Galactokinase Family
IPR006205 Mevalonate kinase Mev_gal_kin Family
IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase Mev_decarb Family
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain
IPR016005 Phosphomevalonate kinase, ERG8 Pmev_kin_ERG8 Family
IPR005916 Phosphomevalonate kinase, eukaryotic Pmev_kin_euk Family
IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase IspE Family
IPR004422 GHMP kinase group 1 GHMP_kin Family
IPR005917 Phosphomevalonate kinase, Gram-positive Pmev_kin_Gpos Family
IPR000870 Homoserine kinase Homoserine_kinase Family
IPR001174 Galactokinase/homoserine kinase Galkinase Family
IPR014606 D,D-heptose 7-phosphate kinase Heptose_7-P_kinase Family
IPR010189 Shikimate kinase, archaea SK_arc Family
IPR012369 Galactokinase, glycosyltransferase Galk_glycosyltransferase Family
IPR012043 Pantoate kinase PoK Family
IPR012363 Propanediol utilisation/coumermycin biosynthesis, PduX-related PduX Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Tsay YH Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. 1991 Mol Cell Biol 11 620-31
Lee M Identification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene. 1999 Arch Biochem Biophys 372 135-42
Byres E Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J Mol Biol 371 540-53

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)