InterPro : IPR000232

Name  Heat shock factor (HSF)-type, DNA-binding Short Name  HSF_DNA-bd
Type  Domain Description  Heat shock factor (HSF) is a transcriptional activator of heat shock genes[]: it binds specifically to heat shock promoter elements, which arepalindromic sequences rich with repetitive purine and pyrimidine motifs [].Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, butheat shock activation results in relocalisation to the nucleus [].Each HSF monomer contains one C-terminal and three N-terminal leucine zipperrepeats []. Point mutations in these regions result in disruption ofcellular localisation, rendering the protein constitutively nuclear [].Two sequences flanking the N-terminal zippers fit the consensus of a bi-partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus []. The DNA-binding componentof HSF lies to the N terminus of the first NLS region, and is referred toas the HSF domain.
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1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Clos J Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation. 1990 Cell 63 1085-97
Rabindran SK Molecular cloning and expression of a human heat shock factor, HSF1. 1991 Proc Natl Acad Sci U S A 88 6906-10
Schuetz TJ Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. 1991 Proc Natl Acad Sci U S A 88 6911-5



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)