InterPro : IPR005097

Name  Saccharopine dehydrogenase / Homospermidine synthase Short Name  Saccharopine_DH/HSpermid_syn
Type  Family Description  This entry represents saccharopine dehydrogenase and homospermidine synthase.Saccharopine dehydrogenase () catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine []. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase. Saccharopine is an intermediate in lysine metabolism.Homospermidine synthase (HSS) () catalyses the synthesis of the polyamine homospermidine from 2 putrescine molecules in an NAD+-dependent reaction []. HSS evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase [, ]and the structure of HSS is related to lysine metabolic enzymes [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Tholl D Purification, molecular cloning and expression in Escherichia coli of homospermidine synthase from Rhodopseudomonas viridis. 1996 Eur J Biochem 240 373-9
Vashishtha AK Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. 2009 Biochemistry 48 5899-907
Lee J An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. 2009 J Biol Chem 284 9899-907
Shaw FL Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine. 2010 J Biol Chem 285 14711-23

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)