InterPro : IPR001156

Name  Transferrin-like domain Short Name  Transferrin-like_dom
Type  Domain Description  Transferrins are eukaryotic iron-binding glycoproteins that control the level of free iron in biological fluids []. Evidence suggests that members of the TF family arose from the duplication and fusion of two homologous domains, with each duplicated domain binding one iron atom. Members of the family include blood serotransferrin (siderophilin); milk lactotransferrin (lactoferrin); egg white ovotransferrin (conalbumin); and membrane-associated melanotransferrin. Family members that do not bind iron have also been discovered, including inhibitor of carbonic anhydrase (ICA), which strongly binds to and inhibits certain isoforms of carbonic anhydrase [].This entry represents the transferrin-like domain, which can be further divided into two subdomains that form a cleft inside of which the iron atom is bound in iron-transporting transferrin []. The iron-coordinating residues consist of an aspartic acid, two tyrosines and a histidine, as well as an arginine that coordinates a requisite anion. In addition to iron and anion liganding residues, the transferrin-like domain contains conserved cysteine residues involved in disulphide bond formation.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR018195 Transferrin family, iron binding site Transferrin_Fe_BS Binding_site

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Crichton RR Iron transport and storage. 1987 Eur J Biochem 164 485-506
Anderson BF Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution. 1989 J Mol Biol 209 711-34
Eckenroth BE The structure and evolution of the murine inhibitor of carbonic anhydrase: a member of the transferrin superfamily. 2010 Protein Sci 19 1616-26

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)