InterPro : IPR014730

Name  Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Short Name  ETF_a/b_N
Type  Domain Description  Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II) []. ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP [, , , , ]. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical alpha-beta-alpha sandwich fold, while domain II forms an alpha-beta-alpha sandwich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides.This entry represents the N-terminal domain of both the alpha and beta subunits from Group I and Group II ETFs.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR000049 Electron transfer flavoprotein, beta-subunit, conserved site ET-Flavoprotein_bsu_CS Conserved_site

1 Found In

Id Name Short Name Type
IPR001308 Electron transfer flavoprotein, alpha subunit ETF_a Family

1 Parent Features

Id Name Short Name Type
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold Rossmann-like_a/b/a_fold Domain

6 Publications

First Author Title Year Journal Volume Pages
Finocchiaro G Biosynthesis, molecular cloning and sequencing of electron transfer flavoprotein. 1990 Prog Clin Biol Res 321 637-52
Tsai MH Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. 1995 Res Microbiol 146 397-404
Roberts DL Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. 1996 Proc Natl Acad Sci U S A 93 14355-60
Roberts DL Crystal structure of Paracoccus denitrificans electron transfer flavoprotein: structural and electrostatic analysis of a conserved flavin binding domain. 1999 Biochemistry 38 1977-89
Weidenhaupt M Bradyrhizobium japonicum possesses two discrete sets of electron transfer flavoprotein genes: fixA, fixB and etfS, etfL. 1996 Arch Microbiol 165 169-78
Leys D Extensive conformational sampling in a ternary electron transfer complex. 2003 Nat Struct Biol 10 219-25

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)