InterPro : IPR012011

Name  von Willebrand factor Short Name  VWF
Type  Family Description  von Willebrand factor (vWF) is a multimeric adhesive protein that plays a key role in platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury []. Binding of vWF to platelet membrane glycoprotein GPIb-alpha () of the GPIb-IX-V complex supports the arrest of bleeding after tissue trauma. The rapid association of GP1b-alpha with vWF not only initiates platelet deposition at the sites of vascular injury but is essential for maintaining thrombus growth in blood flowing at high shear rates.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR002035 von Willebrand factor, type A VWF_A Domain
IPR002919 Trypsin Inhibitor-like, cysteine rich domain TIL_dom Domain
IPR001846 von Willebrand factor, type D domain VWF_type-D Domain
IPR001007 von Willebrand factor, type C VWF_C Domain
IPR006207 Cystine knot, C-terminal Cys_knot_C Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Ruggeri ZM Von Willebrand factor, platelets and endothelial cell interactions. 2003 J Thromb Haemost 1 1335-42

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)