InterPro : IPR015947

Name  PUA-like domain Short Name  PUA-like_domain
Type  Domain Description  This entry represents domains with a PUA-like structure, consisting of a pseudo-barrel composed of mixed folded sheets of five strands. This structural motif is found in:PUA-containing proteins.The N-terminal of ATP sulphurylases, which contains extra structures, some similar to the PK beta-barrel domain [].Several bacterial hypothetical proteins, such as the N-terminal domain of YggJ [].The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found []. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [, ]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA []. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



6 Child Features

Id Name Short Name Type
IPR002478 PUA domain PUA Domain
IPR007374 ASCH domain ASCH_domain Domain
IPR025980 ATP-sulfurylase PUA-like domain ATP-Sase_PUA-like_dom Domain
IPR002740 EVE domain EVE_domain Domain
IPR015225 tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal tRNA_psdUridine_synth_fam2_C Domain
IPR015240 tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal tRNA_sdUridine_synth_fam1_C Domain

0 Contains

5 Found In

Id Name Short Name Type
IPR005155 Ribosome biogenesis factor NIP7-like Rbsml_synth_fac_NIP7-like Family
IPR006700 Ribosomal RNA small subunit methyltransferase E rRNA_ssu_MeTrfase-E Family
IPR022430 Conserved hypothetical protein CHP03684 CHP03684 Family
IPR020792 Sulphate adenylyltransferase, subgroup SO4_adenylyltransferase_subgr Family
IPR009326 Protein of unknown function DUF984 DUF984 Family

0 Parent Features

7 Publications

First Author Title Year Journal Volume Pages
Li L Crystal structure of an H/ACA box ribonucleoprotein particle. 2006 Nature 443 302-7
Aravind L Novel predicted RNA-binding domains associated with the translation machinery. 1999 J Mol Evol 48 291-302
Pérez-Arellano I The PUA domain - a structural and functional overview. 2007 FEBS J 274 4972-84
Hallberg BM The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. 2006 J Mol Biol 360 774-87
Sabina J The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. 2006 J Biol Chem 281 6993-7001
Forouhar F Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. 2003 Proteins 53 329-32
Ullrich TC Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. 2001 EMBO J 20 316-29

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)