InterPro : IPR009080

Name  Aminoacyl-tRNA synthetase, class 1a, anticodon-binding Short Name  tRNAsynth_1a_anticodon-bd
Type  Domain Description  Aminoacyl-tRNA synthetase (aaRS) is akey enzyme during protein biosynthesis. Each aaRS contains a catalytic central domain (CCD), responsible for activating amino acid, and an anticodon-binding domain (ABD), necessary for binding the anticodon in cognate tRNA. aaRSs are classified into class I and II (aaRS-I and aaRS-II) based on the topologies of CCDs. Whereas the structure of the CCDs is similar among the members of each of the two different aaRS classes, the ABDs are diverse in structure [].The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Both classes of tRNA synthetases have been subdivided into three subclasses, designated Ia, Ib, Ic and IIa, IIb, IIc.This domain represents the anticodon binding domain (ABD) of class Ia aminoacyl-tRNA synthetases, and also matches the ABD of glycine tRNA synthetases.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



3 Child Features

Id Name Short Name Type
IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding M/V/L/I-tRNA-synth_anticd-bd Domain
IPR008909 DALR anticodon binding DALR_anticod-bd Domain
IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR Cys-tRNA-synt_Ia_DALR Domain

2 Contains

Id Name Short Name Type
IPR008909 DALR anticodon binding DALR_anticod-bd Domain
IPR010663 Zinc finger, DNA glycosylase/AP lyase/isoleucyl tRNA synthetase Znf_DNA_glyclase/IsotRNA_synth Domain

2 Found In

Id Name Short Name Type
IPR001278 Arginine-tRNA ligase Arg-tRNA-ligase Family
IPR020791 Leucine-tRNA ligase, archaeal Leu-tRNA-lgase_arc Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Tang SN Evolution of different oligomeric glycyl-tRNA synthetases. 2005 FEBS Lett 579 1441-5

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)