InterPro : IPR002121

Name  HRDC domain Short Name  HRDC_dom
Type  Domain Description  The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed alpha-hairpin subdomains, and is involved in interactions with DNA and protein. HRDC domains are found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins []. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation alpha-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR010997 HRDC-like HRDC-like Domain

4 Found In

Id Name Short Name Type
IPR004589 DNA helicase, ATP-dependent, RecQ type DNA_helicase_ATP-dep_RecQ Family
IPR006293 DNA helicase, ATP-dependent, RecQ type, bacterial DNA_helicase_ATP-dep_RecQ_bac Family
IPR006292 Ribonuclease D RNase_D Family
IPR022758 Sgs1 RecQ helicase Helicase_Sgs1 Domain

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Morozov V A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases. 1997 Trends Biochem Sci 22 417-8
Todone F Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. 2001 Mol Cell 8 1137-43
Liu Z The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. 1999 Structure 7 1557-66
Armache KJ Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. 2005 J Biol Chem 280 7131-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)