InterPro : IPR027105

Name  U4/U6 small nuclear ribonucleoprotein Prp31 Short Name  Prp31
Type  Family Description  Prp31 is a component of the U4/U6-U5 snRNP complex that is involved in pre-mRNA splicing []. It is required for U4/U6.U5 tri-snRNP formation [, ]. Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11). RP leads to degeneration of retinal photoreceptor cells [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Liu S Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. 2007 Science 316 115-20
Makarova OV Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing. 2002 EMBO J 21 1148-57
Weidenhammer EM The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae. 1996 Nucleic Acids Res 24 1164-70
Al-Maghtheh M Evidence for a major retinitis pigmentosa locus on 19q13.4 (RP11) and association with a unique bimodal expressivity phenotype. 1996 Am J Hum Genet 59 864-71
Vithana EN A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). 2001 Mol Cell 8 375-81
Bishop DT Isolation of an essential Schizosaccharomyces pombe gene, prp31(+), that links splicing and meiosis. 2000 Nucleic Acids Res 28 2214-20

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)