InterPro : IPR000566

Name  Lipocalin/cytosolic fatty-acid binding domain Short Name  Lipocln_cytosolic_FA-bd_dom
Type  Domain Description  Proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids share limitedregions of sequence homology and a common tertiary structure architecture [, , ,, ]. This is an eight stranded antiparallel beta-barrel with a repeated + 1 topology enclosinga internal ligand binding site [, ]. The name 'lipocalin' has been proposed []forthis protein family, but cytosolic fatty-acid binding proteins are also included. The sequences of most members of the family, the core or kernal lipocalins, are characterised bythree short conserved stretches of residues, while others, the outlier lipocalin group, share only one or two of these[, ]. Proteins known to belong to this family include alpha-1-microglobulin (protein HC);alpha-1-acid glycoprotein (orosomucoid) []; aphrodisin; apolipoprotein D; beta-lactoglobulin; complementcomponent C8 gamma chain []; crustacyanin []; epididymal-retinoic acid binding protein(E-RABP) []; insectacyanin; odorant-binding protein (OBP); humanpregnancy-associated endometrial alpha-2globulin; probasin (PB), a rat prostatic protein; prostaglandin D synthase () []; purpurin; VonEbner's gland protein (VEGP) []; and lizard epididymal secretory protein IV (LESP IV) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR000463 Cytosolic fatty-acid binding Fatty_acid-bd Domain

0 Contains

4 Found In

Id Name Short Name Type
IPR001500 Alpha-1-acid glycoprotein A1A_glycop Family
IPR002968 Alpha-1-microglobulin A1-microglobln Family
IPR002969 Apolipoprotein D ApolipopD Family
IPR003057 Invertebrate colouration protein Invtbrt_color Family

1 Parent Features

Id Name Short Name Type
IPR012674 Calycin Calycin Domain

13 Publications

First Author Title Year Journal Volume Pages
Flower DR Mouse oncogene protein 24p3 is a member of the lipocalin protein family. 1991 Biochem Biophys Res Commun 180 69-74
Keen JN Complete sequence and model for the A2 subunit of the carotenoid pigment complex, crustacyanin. 1991 Eur J Biochem 197 407-17
Kock K Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins. 1994 Eur J Biochem 221 905-16
Pervaiz S Homology and structure-function correlations between alpha 1-acid glycoprotein and serum retinol-binding protein and its relatives. 1987 FASEB J 1 209-14
Morel L LESP, an androgen-regulated lizard epididymal secretory protein family identified as a new member of the lipocalin superfamily. 1993 J Biol Chem 268 10274-81
Haefliger JA Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. 1991 Mol Immunol 28 123-31
Kremer JM Drug binding to human alpha-1-acid glycoprotein in health and disease. 1988 Pharmacol Rev 40 1-47
Igarashi M Structural organization of the gene for prostaglandin D synthase in the rat brain. 1992 Proc Natl Acad Sci U S A 89 5376-80
Cowan SW Crystallographic refinement of human serum retinol binding protein at 2A resolution. 1990 Proteins 8 44-61
Flower DR Structure and sequence relationships in the lipocalins and related proteins. 1993 Protein Sci 2 753-61
Newcomer ME Structure of the epididymal retinoic acid binding protein at 2.1 A resolution. 1993 Structure 1 7-18
Godovac-Zimmermann J The structural motif of beta-lactoglobulin and retinol-binding protein: a basic framework for binding and transport of small hydrophobic molecules? 1988 Trends Biochem Sci 13 64-6
Peitsch MC The first lipocalin with enzymatic activity. 1991 Trends Biochem Sci 16 363

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)