InterPro : IPR006036

Name  Potassium uptake protein TrkA Short Name  K_uptake_TrkA
Type  Family Description  The Trk system is a low to medium affinity potassium uptake system, widely found in both in bacteria and archaea, where the uptake of K(+) is believed to be linked to H(+) symport []. The core Trk system consists of two proteins, the integral membrane K(+)-translocating protein TrkH (or TrkG), and the NAD-binding peripheral membrane protein TrkA [, ]. In Escherichia colithe activity of TrkH is dependent on the ATP-binding protein SapD (also known as TrkE) which is part of the SapABCDF ABC transporter of unkown function. Not all Trk systems are dependent on SapD however - it is thought that these may utilise ATP-binding proteins from other ABC transporters [].Sequence analysis of TrkA reveals that the protein consists of 2 tandemly arrayed halves that are 22% identical, a situation that might have arisen through gene duplication. TrkA also exhibits similarity to other Escherichia coliproteins [], in particular KefC, a glutathione- regulated efflux protein [], and to various dehydrogenase proteins that possess NAD+binding sites.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR023941 Glutathione-regulated potassium-efflux system protein KefC K_H_efflux_KefC Family

2 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR003148 Regulator of K+ conductance, N-terminal RCK_N Domain

0 Found In

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Durell SR Evolutionary relationship between K(+) channels and symporters. 1999 Biophys J 77 775-88
Buurman ET Multiple paths for nonphysiological transport of K+ in Escherichia coli. 2004 J Bacteriol 186 4238-45
Nakamura T Cloning of the trkAH gene cluster and characterization of the Trk K(+)-uptake system of Vibrio alginolyticus. 1998 Microbiology 144 ( Pt 8) 2281-9
Domene C Molecular dynamics simulations of the TrkH membrane protein. 2012 Biochemistry 51 1559-65
Parra-Lopez C A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium. 1994 EMBO J 13 3964-72
Munro AW The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli. 1991 Mol Microbiol 5 607-16

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)