InterPro : IPR005888

Name  dTDP-glucose 4,6-dehydratase Short Name  dTDP_Gluc_deHydtase
Type  Family Description  The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia colidTDP-glucose 4,6-dehydratase) takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tightly bound NAD+as the coenzyme for transiently oxidizing the substrate, activating it for the dehydration step []. This and other 4,6-dehydratases catalyze the first committed step in all 6-deoxysugar biosynthetic pathways described to date. Numerous6-deoxysugars are used in bacterial lipopolysaccharide production as well as in the biosynthesis of a diverse array of secondary metabolites.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR026390 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family EDH_00030 Family

1 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Hegeman AD Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase. 2002 Biochemistry 41 2797-804

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)