InterPro : IPR007241

Name  Autophagy-related protein 9 Short Name  Autophagy-rel_prot_9
Type  Family Description  Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p. It is found in the vacuole []. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Auotphagy protein 16 (Atg16) has been shown to be bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, possibly serving as a marker for a specialised compartment essential for these vesicle-mediated alternative targeting pathways [].
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InterPro protein domain ID --> Contigs

 

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4 Publications

First Author Title Year Journal Volume Pages
George MD Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. 2000 Mol Biol Cell 11 969-82
Suzuki K The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. 2001 EMBO J 20 5971-81
Mizushima N Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. 1999 EMBO J 18 3888-96
Noda T Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. 2000 J Cell Biol 148 465-80



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)