InterPro : IPR004405

Name  Translation release factor pelota Short Name  Transl_rel_pelota
Type  Family Description  Pelota (known as DOM34 in yeast) binds Hbs1, which is EF1-alpha-related subfamily GTPase, and is considered to play a crucial role in mRNA surveillance for protein synthesis []. It is involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. Pelota/Hbs1 were shown to promote dissociation of stalled elongation complexes and release of intact peptidyl-tRNA in the presence of the ATP-binding cassette protein ABCE1 []. Pelota is conserved in eukaryotes and archaea [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR023521 Translation release factor pelota, archaea Pelota_arc Family

3 Contains

Id Name Short Name Type
IPR005142 eRF1 domain 3 eRF1_3 Domain
IPR005141 eRF1 domain 2 eRF1_2 Domain
IPR005140 eRF1 domain 1/Pelota-like eRF1_1_Pelota Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Pisareva VP Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. 2011 EMBO J 30 1804-17
Doma MK RNA quality control in eukaryotes. 2007 Cell 131 660-8
Saito K Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis. 2010 Proc Natl Acad Sci U S A 107 19242-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)