InterPro : IPR001664

Name  Intermediate filament protein Short Name  IF
Type  Family Description  Intermediate filaments (IF) [, , ]are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin, desmin, glial fibrillary acidic protein (GFAP), peripherin, and plasticin.Type IV: Neurofilaments L, H and M, alpha-internexin and nestin.Type V: Nuclear lamins A, B1, B2 and C.Type VI: Nestin.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices, with at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical, and which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related, they have limited sequence homologies except in several regions of the rod domain.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



11 Child Features

Id Name Short Name Type
IPR027696 Lamin Lamin Family
IPR027701 Glial fibrillary acidic protein GFAP Family
IPR002957 Keratin, type I Keratin_I Family
IPR016451 Intermediate filament, ifa/ifb Intermed_filament_ifa/ifb Family
IPR003054 Keratin, type II Keratin_II Family
IPR027692 Neurofilament light polypeptide NF-L Family
IPR027698 Desmin DES Family
IPR027697 Neurofilament medium polypeptide NF-M Family
IPR027699 Vimentin Vimentin Family
IPR027702 Syncoilin Syncoilin Family
IPR027703 Alpha-internexin Alpha-Inx Family

1 Contains

Id Name Short Name Type
IPR018039 Intermediate filament protein, conserved site Intermediate_filament_CS Conserved_site

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Quinlan R Intermediate filament proteins. 1995 Protein Profile 2 795-952
Steinert PM Molecular and cellular biology of intermediate filaments. 1988 Annu Rev Biochem 57 593-625
Stewart M Intermediate filaments: structure, assembly and molecular interactions. 1990 Curr Opin Cell Biol 2 91-100

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)