InterPro : IPR001664

Name  Intermediate filament protein Short Name  IF
Type  Family Description  Intermediate filaments (IF) [, , ]are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin, desmin, glial fibrillary acidic protein (GFAP), peripherin, and plasticin.Type IV: Neurofilaments L, H and M, alpha-internexin and nestin.Type V: Nuclear lamins A, B1, B2 and C.Type VI: Nestin.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices, with at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical, and which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related, they have limited sequence homologies except in several regions of the rod domain.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

11 Child Features

Id Name Short Name Type
IPR027696 Lamin Lamin Family
IPR027701 Glial fibrillary acidic protein GFAP Family
IPR002957 Keratin, type I Keratin_I Family
IPR016451 Intermediate filament, ifa/ifb Intermed_filament_ifa/ifb Family
IPR003054 Keratin, type II Keratin_II Family
IPR027692 Neurofilament light polypeptide NF-L Family
IPR027698 Desmin DES Family
IPR027697 Neurofilament medium polypeptide NF-M Family
IPR027699 Vimentin Vimentin Family
IPR027702 Syncoilin Syncoilin Family
IPR027703 Alpha-internexin Alpha-Inx Family

1 Contains

Id Name Short Name Type
IPR018039 Intermediate filament protein, conserved site Intermediate_filament_CS Conserved_site

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Quinlan R Intermediate filament proteins. 1995 Protein Profile 2 795-952
Steinert PM Molecular and cellular biology of intermediate filaments. 1988 Annu Rev Biochem 57 593-625
Stewart M Intermediate filaments: structure, assembly and molecular interactions. 1990 Curr Opin Cell Biol 2 91-100



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)