InterPro : IPR000225

Name  Armadillo Short Name  Armadillo
Type  Repeat Description  The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogastersegment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes, including intracellular signalling and cytoskeletal regulation, and include such proteins as beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumour suppressor protein, and the nuclear transport factor importin-alpha, amongst others []. A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants, some Arm-repeat proteins function in intracellular signalling like their mammalian counterparts, while others have novel functions [].The 3-dimensional fold of an armadillo repeat is known from the crystal structure of beta-catenin, where the 12 repeats form a superhelix of alpha helices with three helices per unit []. The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR016024 Armadillo-type fold ARM-type_fold Domain
IPR011989 Armadillo-like helical ARM-like Domain
IPR013284 Beta-catenin Beta-catenin Family
IPR016617 Uncharacterised conserved protein UCP013899, metal binding UCP013899_metal-bd Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Huber AH Three-dimensional structure of the armadillo repeat region of beta-catenin. 1997 Cell 90 871-82
Hatzfeld M The armadillo family of structural proteins. 1999 Int Rev Cytol 186 179-224
Coates JC Armadillo repeat proteins: beyond the animal kingdom. 2003 Trends Cell Biol 13 463-71



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)