InterPro : IPR002884

Name  Proprotein convertase, P Short Name  PrprotnconvertsP
Type  Domain Description  This domain, termed the P domain is approximately 150 amino acids in length and C-terminal to a serine endopeptidase domain which belong to MEROPS peptidase family S8 (clan SB), subfamily S8B (kexin). The domain is primarily associated with the calcium-dependent serine endopeptidases, kex2/subtilisin proprotein convertases (PCs), which have been identified in all eukaryotes []and in the gammaproteobacteria, Nostoc (cyanobacteria) and in Streptomyces avermitilis.The P domain appears necessary for folding and maintaining the endopeptidase catalytic domain and to regulate its calcium and acidic pH dependence. In addition, contained within the middle of the P domain in most PC family members is the cognate integrin binding RGD sequence [], which may be required for intracellular compartmentalization and maintenance of enzyme stability within the ER. The integrity of the RGD sequence of proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking [, ]. The carboxy-terminal tail provides uniqueness to each PC family member being the least conserved region of all convertases [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR017323 Lysyl endopeptidase Lysyl_endo-pept Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Lusson J The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. 1997 Biochem J 326 ( Pt 3) 737-44
Rovère C The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1. 1999 J Biol Chem 274 12461-7
Seidah NG Eukaryotic protein processing: endoproteolysis of precursor proteins. 1997 Curr Opin Biotechnol 8 602-7
Thacker C A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family. 2000 Bioessays 22 545-53

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)