InterPro : IPR027707

Name  Troponin T Short Name  TNNT
Type  Family Description  The troponin (Tn) complex regulates calcium-induced muscle contraction. Tn contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT), which is required for Ca(2+)-mediated activation of actomyosin ATPase activity [, ]. Three different troponin T genes that encode tissue-specific isoforms of subunit T have been found in mammals and birds, encoding cardiac (TNNT2), slow (TNNT1), and fast (TNNT3) skeletal muscle TnT isoforms [, , , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR027708 Troponin T, fast skeletal muscle Tnnt3 Family

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001978 Troponin Troponin Family

6 Publications

First Author Title Year Journal Volume Pages
Wei B Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function. 2011 Arch Biochem Biophys 505 144-54
Gallon CE Differences in myofilament calcium sensitivity in rat psoas fibers reconstituted with troponin T isoforms containing the alpha- and beta-exons. 2006 Arch Biochem Biophys 456 127-34
Cooper TA A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing. 1985 J Biol Chem 260 11140-8
Jin JP Complete nucleotide sequence and structural organization of rat cardiac troponin T gene. A single gene generates embryonic and adult isoforms via developmentally regulated alternative splicing. 1992 J Mol Biol 227 1269-76
Farza H Genomic organisation, alternative splicing and polymorphisms of the human cardiac troponin T gene. 1998 J Mol Cell Cardiol 30 1247-53
Huang QQ Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene. 1999 Gene 229 1-10

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)