InterPro : IPR016641

Name  Nascent polypeptide-associated complex subunit alpha Short Name  EGD2/NACA
Type  Family Description  In Saccharomyces cerevisiae, nascent polypeptide-associated complex subunit alpha (also known as EGD2) is a component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting [, , ]. In human and mouse, nascent polypeptide-associated complex subunit alpha (known as NACA) prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR002715 Nascent polypeptide-associated complex NAC domain Nas_poly-pep-assoc_cplx_dom Domain
IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal UBA/Ts_N Domain

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Wiedmann B The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane. 1999 FEBS Lett 458 51-4
George R The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. 1998 Proc Natl Acad Sci U S A 95 2296-301
Fünfschilling U Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria. 1999 Mol Biol Cell 10 3289-99
Möller I Unregulated exposure of the ribosomal M-site caused by NAC depletion results in delivery of non-secretory polypeptides to the Sec61 complex. 1998 FEBS Lett 441 1-5
Yotov WV Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factor. 1996 Genes Dev 10 1763-72

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)