InterPro : IPR002109

Name  Glutaredoxin Short Name  Glutaredoxin
Type  Domain Description  Glutaredoxins [, , ], also known as thioltransferases (disulphide reductases, are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system []. Glutaredoxin functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active centre disulphide bond []. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulphide bond.Glutaredoxin has been sequenced in a variety of species. On the basis of extensive sequence similarity, it has been proposed []that Vaccinia virusprotein O2L is most probably a glutaredoxin. Finally, it must be noted that Bacteriophage T4thioredoxin seems also to be evolutionary related. In position 5 of the pattern T4 thioredoxin has Val instead of Pro.This entry represents Glutaredoxin.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR014025 Glutaredoxin subgroup Glutaredoxin_subgr Domain

1 Contains

Id Name Short Name Type
IPR011767 Glutaredoxin active site GLR_AS Active_site

11 Found In

Id Name Short Name Type
IPR012336 Thioredoxin-like fold Thioredoxin-like_fold Domain
IPR004480 Monothiol glutaredoxin-related Monothiol_GRX-rel Family
IPR004502 Thioredoxins/glutaredoxin Thio_glut Family
IPR014434 Monothiol glutaredoxin Monothiol_GRX Family
IPR011911 Glutaredoxin-like protein, YruB GlrX_YruB Family
IPR011915 Glutaredoxin-like protein, actinobacteria GlrX_actino Family
IPR011900 Glutaredoxin, GrxC GRX_bact Family
IPR011902 Glutaredoxin, GrxA GRXA Family
IPR011903 Glutaredoxin-like domain Glutaredoxin-like_dom Family
IPR011905 Glutaredoxin-like, plant II GlrX-like_pln_2 Family
IPR011909 Glutaredoxin-like protein NrdH GlrX_NrdH Family

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Holmgren A Thioredoxin and glutaredoxin: small multi-functional redox proteins with active-site disulphide bonds. 1988 Biochem Soc Trans 16 95-6
Gleason FK Thioredoxin and related proteins in procaryotes. 1988 FEMS Microbiol Rev 4 271-97
Holmgren A Thioredoxin and glutaredoxin systems. 1989 J Biol Chem 264 13963-6
Johnson GP Vaccinia virus encodes a protein with similarity to glutaredoxins. 1991 Virology 181 378-81
Fernandes AP Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. 2004 Antioxid Redox Signal 6 63-74
Foloppe N The glutaredoxin -C-P-Y-C- motif: influence of peripheral residues. 2004 Structure 12 289-300

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)