InterPro : IPR004692

Name  Preprotein translocase SecG subunit Short Name  SecG
Type  Family Description  Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocasepathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them tothe translocase component []. From there, the mature proteins are either targeted to the outermembrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterialchromosome.The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integralmembrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release ofthe mature peptide into the periplasm (SecD and SecF) []. The chaperone protein SecB []is a highly acidic homotetrameric protein that exists as a "dimer of dimers" in the bacterial cytoplasm.SecB maintains preproteins in an unfolded state after translation, and targets these to the peripheral membraneprotein ATPase SecA for secretion []. Together withSecY and SecG, SecE forms a multimeric channel through which preproteinsare translocated, using both proton motive forces and ATP-driven secretion. The latter is mediated by SecA. SecG has two transmembranedomains, both of which contribute to the recognition of preprotein signalsequences by the translocation complex []. The protein also undergoesmembrane topology inversion when coupled to the SecA cycle [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Bieker KL The sec and prl genes of Escherichia coli. 1990 J Bioenerg Biomembr 22 291-310
Driessen AJ SecB, a molecular chaperone with two faces. 2001 Trends Microbiol 9 193-6
Müller JP Effects of pre-protein overexpression on SecB synthesis in Escherichia coli. 1999 FEMS Microbiol Lett 176 219-27
Douville K SecYEG and SecA are the stoichiometric components of preprotein translocase. 1995 J Biol Chem 270 20106-11
Veenendaal AK Mapping the sites of interaction between SecY and SecE by cysteine scanning mutagenesis. 2001 J Biol Chem 276 32559-66

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)