InterPro : IPR001304

Name  C-type lectin Short Name  C-type_lectin
Type  Domain Description  Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions []. There are at least twelve structural families of lectins:C-type lectins, which are Ca+-dependent. S-type (galectins), a widespread family of glycan-binding proteins [].I-type, which have an immunoglobulin-like fold and can recognise sialic acids, other sugars and glycosaminoglycans [].P-type, which bind phosphomannosyl receptors [].Pentraxins [].(Trout) egg lectins.Calreticulin and calnexin, which act as molecular chaperones of the endoplasmic reticulum [].ERGIC-53 and VIP-36 [].Discoidins [].Eel aggutinins (fucolectins) [].Annexin lectins [].Fibrinogen-type lectins, which includes ficolins, tachylectins 5A and 5B, and Limax flavus(Spotted garden slug) agglutinin (these proteins have clear distinctions from one another, but they share a homologous fibrinogen-like domain used for carbohydrate binding).Also unclassified orphan lectins, including amphoterin, Cel-II, complement factor H, thrombospondin, sailic acid-binding lectins, adherence lectin, and cytokins (such as tumour necrosis factor and several interleukins).C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [].Therefore, lectins are a diverse group of proteins, both in terms of structure and activity. Carbohydrate binding ability may have evolved independently and sporadically in numerous unrelated families, where each evolved a structure that was conserved to fulfil some other activity and function. In general, animal lectins act as recognition molecules within the immune system, their functions involving defence against pathogens, cell trafficking, immune regulation and the prevention of autoimmunity [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

1 Contains

Id Name Short Name Type
IPR018378 C-type lectin, conserved site C-type_lectin_CS Conserved_site

6 Found In

Id Name Short Name Type
IPR002352 Eosinophil major basic protein Eosinophil_major_basic Family
IPR002353 Type-2 ice-structuring protein AntifreezeII Family
IPR002396 Selectin superfamily Selectin_superfamily Family
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR016348 L-selectin L-selectin Family
IPR006228 Polycystin cation channel Polycystin_cat Domain

1 Parent Features

Id Name Short Name Type
IPR016186 C-type lectin-like C-type_lectin-like Domain

13 Publications

First Author Title Year Journal Volume Pages
Honda S Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins. 2000 J Biol Chem 275 33151-7
Sharon N The structural basis for carbohydrate recognition by lectins. 2001 Adv Exp Med Biol 491 1-16
Kilpatrick DC Animal lectins: a historical introduction and overview. 2002 Biochim Biophys Acta 1572 187-97
Elola MT Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. 2007 Cell Mol Life Sci 64 1679-700
Angata T I-type lectins. 2002 Biochim Biophys Acta 1572 294-316
Dahms N P-type lectins. 2002 Biochim Biophys Acta 1572 317-40
Bottazzi B Pentraxins as a key component of innate immunity. 2006 Curr Opin Immunol 18 10-5
Ireland BS In vitro assays of the functions of calnexin and calreticulin, lectin chaperones of the endoplasmic reticulum. 2006 Methods Mol Biol 347 331-42
Arar C ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells. 1995 J Biol Chem 270 3551-3
Kiedzierska A Structural similarities and functional diversity of eukaryotic discoidin-like domains. 2007 Biochim Biophys Acta 1774 1069-78
Turnay J Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins. 2005 Biochem J 389 899-911
McGreal EP Divergent roles for C-type lectins expressed by cells of the innate immune system. 2004 Mol Immunol 41 1109-21
Cambi A Dual function of C-type lectin-like receptors in the immune system. 2003 Curr Opin Cell Biol 15 539-46



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)