InterPro : IPR016181

Name  Acyl-CoA N-acyltransferase Short Name  Acyl_CoA_acyltransferase
Type  Domain Description  This entry represents a structural domain found in several acyl-CoA acyltransferase enzymes. This domain has a 3-layer alpha/beta/alpha structure that contains mixed beta-sheets, and can be found in the following proteins:N-acetyl transferase (NAT) family members, including aminoglycoside N-acetyltransferases [], the histone acetyltransferase domain of P300/CBP associating factor PCAF [], the catalytic domain of GCN5 histone acetyltransferase [], and diamine acetyltransferase 1 [].Autoinducer synthetases, such as protein LasI []and acyl-homoserinelactone synthase EsaI [].Leucyl/phenylalanyl-tRNA-protein transferase (LFTR), a close relative of the non-ribosomal peptidyltransferases; there is a deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events [].Ornithine decarboxylase antizyme, which may have evolved a different function for this domain, although the putative active site maps to the same location in the common fold.Arginine N-succinyltransferase, alpha chain, AstA, which contains an extra C-terminal domain that is similar to the double psi beta-barrel fold domain (missing one strand and untangled psi-loops).Several proteins carry a duplication of this domain, which consists of two NAT-like domains swapped with the C-terminal strands, including:N-myristoyl transferase (NMT) [].FemXAB nonribosomal peptidyltransferases, including methicillin-resistance protein FemA (transfer glycyl residue from tRNA-Gly) []and peptidyltransferase FemX [].Hypothetical protein cg14615-pa from Drosophila melanogaster(Fruit fly).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR000182 GNAT domain GNAT_dom Domain

11 Contains

Id Name Short Name Type
IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal MyristoylCoA_TrFase_N Domain
IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal MyristoylCoA_TrFase_C Domain
IPR019467 Histone acetyl transferase HAT1 N-terminal Hat1_N Domain
IPR002717 MOZ/SAS-like protein MOZ_SAS Domain
IPR013653 FR47-like FR47 Domain
IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site MyristoylCoA_TrFase_CS Conserved_site
IPR018311 Autoinducer synthesis, conserved site Autoind_synth_CS Conserved_site
IPR015938 Glycine N-acyltransferase, N-terminal Glycine_N-acyltransferase_N Domain
IPR019432 Siderophore biosynthesis protein, conserved domain Siderophore_biosyn_cons_dom Domain
IPR009658 Domain of unknown function DUF1248 DUF1248 Domain
IPR013652 Glycine N-acyltransferase, C-terminal Glycine_N-acyltransferase_C Domain

11 Found In

Id Name Short Name Type
IPR000903 Myristoyl-CoA:protein N-myristoyltransferase MyristoylCoA_TrFase Family
IPR017380 Histone acetyltransferase type B, catalytic subunit Hist_AcTrfase_B-typ_cat-su Family
IPR003447 FemABX peptidyl transferase FEMABX Family
IPR010313 Glycine N-acyltransferase Glycine_N-acyltransferase Family
IPR007434 Protein of unknown function DUF482 DUF482 Family
IPR007041 Arginine N-succinyltransferase Ast/AOST Arg_N-succinylTrfase_Ast/AOST Family
IPR017650 Arginine N-succinyltransferase AstA Arginine_N-succinylTrfase_AstA Family
IPR017469 PEP-CTERM system-associated, FemAB-related PEP-CTERM_FemAB-rel Family
IPR011242 N-acetylglutamate kinase, DUF619 domain-containing AcGlu_kinase_DUF619-contain Family
IPR010037 FkbH domain FkbH_domain Domain
IPR001690 Autoinducer synthesis protein Autoind_synth Domain

0 Parent Features

10 Publications

First Author Title Year Journal Volume Pages
Burk DL X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members. 2003 Protein Sci 12 426-37
Biarrotte-Sorin S Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition. 2004 Structure 12 257-67
Trievel RC Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. 1999 Proc Natl Acad Sci U S A 96 8931-6
Benson TE X-ray crystal structure of Staphylococcus aureus FemA. 2002 Structure 10 1107-15
Clements A Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A. 1999 EMBO J 18 3521-32
Farazi TA Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. 2001 Biochemistry 40 6335-43
Watson WT Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing. 2002 Mol Cell 9 685-94
Gould TA Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI. 2004 Mol Microbiol 53 1135-46
Bewley MC Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. 2006 Proc Natl Acad Sci U S A 103 2063-8
Dong X The crystal structure of leucyl/phenylalanyl-tRNA-protein transferase from Escherichia coli. 2007 Protein Sci 16 528-34

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)