InterPro : IPR024162

Name  Adaptor protein Cbl Short Name  Adaptor_Cbl
Type  Family Description  Cbl (CasitasB-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins known to date: Cbl, CblB, and CblC/Cbl3 []. Cbls function as ubiquitin E3 ligase proteins, accepting ubiquitin from specific E2 ubiquitin-conjugating enzymes and transferring it to substrates, promoting their degradation []or endocytosis [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

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3 Publications

First Author Title Year Journal Volume Pages
Ollendorff V A third human CBL gene is on chromosome 19. 1998 Int J Oncol 13 1159-61
Miyake S The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. 1998 Proc Natl Acad Sci U S A 95 7927-32
Lee PS The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. 1999 EMBO J 18 3616-28



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)