InterPro : IPR001627

Name  Sema domain Short Name  Semap_dom
Type  Domain Description  The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in plexins [], receptors for multiple classes of semaphorins, in hepatocyte growth factor receptor, and in viral proteins [].The Sema domain is characterised by a conserved set of cysteine residues,which form four disulphide bonds to stabilise the structure. The Sema domainfold is a variation of the beta propeller topology, with seven blades radiallyarranged around a central axis. Each blade contains a four-stranded (strands A to D) antiparallel beta sheet. The inner strand of eachblade (A) lines the channel at the centre of the propeller, with strands B andC of the same repeat radiating outward, and strand D of the next repeatforming the outer edge of the blade. The large size of the Sema domain is notdue to a single inserted domain but results from the presence of additionalsecondary structure elements inserted in most of the blades. The Sema domainuses a 'loop and hook' system to close the circle between the first and thelast blades. The blades are constructed sequentially with an N-terminal beta-strand closing the circle by providing the outermost strand (D) of the seventh(C-terminal) blade. The beta-propeller is further stabilised by an extensionof the N terminus, providing an additional, fifth beta-strand on the outeredge of blade 6 [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR015513 Semaphorin 3E Semaphorin_3E Family
IPR015514 Semaphorin 6C Semaphorin_6C Family
IPR016244 Tyrosine-protein kinase, HGF/MSP receptor Tyr_kinase_HGF/MSP_rcpt Family
IPR015512 Seamphorin 4F Seamphorin_4F Family

1 Parent Features

Id Name Short Name Type
IPR015943 WD40/YVTN repeat-like-containing domain WD40/YVTN_repeat-like_dom Domain

5 Publications

First Author Title Year Journal Volume Pages
Winberg ML Plexin A is a neuronal semaphorin receptor that controls axon guidance. 1998 Cell 95 903-16
Antipenko A Structure of the semaphorin-3A receptor binding module. 2003 Neuron 39 589-98
Love CA The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. 2003 Nat Struct Biol 10 843-8
Stamos J Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. 2004 EMBO J 23 2325-35
Xu X Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. 1998 J Biol Chem 273 22428-34

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)