InterPro : IPR000717

Name  Proteasome component (PCI) domain Short Name  PCI_dom
Type  Domain Description  A homology domain of unclear function, occurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [].Apparently, all of the characterised proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2), Rpn5, Rpn6, Rpn7and Rpn9 []; mammalian proteasome regulatory components p55, p58 and p44.5, and translationinitiation factor 3 complex subunits p110 and INT6 [, ]; ArabidopsisCOP9 and FUS6/COP11 []; mammalian G-protein pathway suppressor GPS1, and severaluncharacterised ORFs from plant, nematodes and mammals. The complete homology domain comprisesapprox. 200 residues, the highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

1 Found In

Id Name Short Name Type
IPR016650 Eukaryotic translation initiation factor 3 subunit E eIF3e Family

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Hofmann K The PCI domain: a common theme in three multiprotein complexes. 1998 Trends Biochem Sci 23 204-5
Chamovitz DA The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. 1996 Cell 86 115-21
Asano K Conservation and diversity of eukaryotic translation initiation factor eIF3. 1997 J Biol Chem 272 1101-9
Asano K Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. 1997 J Biol Chem 272 27042-52
Glickman MH The regulatory particle of the Saccharomyces cerevisiae proteasome. 1998 Mol Cell Biol 18 3149-62

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)