InterPro : IPR006115

Name  6-phosphogluconate dehydrogenase, NADP-binding Short Name  6PGDH_NADP-bd
Type  Domain Description  6-Phosphogluconate dehydrogenase () (6PGD) is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP) [, ]. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved []. The protein is a homodimer in which the monomers act independently []: each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet []. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket []. This family represents the NADP binding domain of 6-phosphogluconate dehydrogenase which adopts a Rossman fold. The C-terminal domain is described in .

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site 3-OH-isobutyrate_DH-rel_CS Conserved_site

5 Found In

Id Name Short Name Type
IPR006113 6-phosphogluconate dehydrogenase, decarboxylating 6PGDH_decarbox Family
IPR011548 3-hydroxyisobutyrate dehydrogenase IsoBut3OH_DH Family
IPR006398 2-hydroxy-3-oxopropionate reductase Tartro_sem_red Family
IPR015815 Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type HIBADH-type Family
IPR004849 6-phosphogluconate dehydrogenase-related protein 6DGDH-related Family

1 Parent Features

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Adams MJ The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. 1983 EMBO J 2 1009-14
Broedel SE Jr Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase. 1990 J Bacteriol 172 4023-31
Reizer A Analysis of the gluconate (gnt) operon of Bacillus subtilis. 1991 Mol Microbiol 5 1081-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)