InterPro : IPR000742

Name  Epidermal growth factor-like domain Short Name  EG-like_dom
Type  Domain Description  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermalgrowth factor (EGF) has been shown [, , , , , ]to be present, in a more or less conserved form, in a large number of other, mostly animal proteins.The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear.However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). TheEGF domain includes six cysteine residues which have been shown (in EGF) to be involved indisulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminalshort two-stranded sheet. Subdomains between the conserved cysteines vary in length.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR013111 EGF-like domain, extracellular EGF_extracell Domain
IPR000152 EGF-type aspartate/asparagine hydroxylation site EGF-type_Asp/Asn_hydroxyl_site PTM
IPR018097 EGF-like calcium-binding, conserved site EGF_Ca-bd_CS Conserved_site

23 Found In

Id Name Short Name Type
IPR015455 Thrombospondin-2 Thrombospondin-2 Family
IPR002049 EGF-like, laminin EGF_laminin Domain
IPR011398 Fibrillin/Microneme protein4 FBN/EtMIC4 Family
IPR015497 Epidermal growth factor receptor ligand EGF_rcpt_ligand Family
IPR008294 Meprin alpha/beta subunit Meprin Family
IPR002396 Selectin superfamily Selectin_superfamily Family
IPR016317 Pro-epidermal growth factor Pro-epidermal_GF Family
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR016348 L-selectin L-selectin Family
IPR008297 Notch Notch Family
IPR022355 Neurogenic locus Notch 4 Notch_4 Family
IPR018250 Neuregulin NRG1 Family
IPR012111 Hemolectin/hemocytin Hml Family
IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator Coagulation_fac_XIIa/HGFA Family
IPR003056 GPCR, family 2, CD97 antigen GPCR_2_CD97 Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR017048 Fibulin-1 Fibulin-1 Family
IPR001491 Thrombomodulin Thrombomodulin Family
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z Pept_S1A_FX Family
IPR011170 Growth factor, vaccinia C11R type GF_C11R Family
IPR017047 Teratocarcinoma-derived growth factor Cripto Cripto_growth_factor Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR017436 Cripto-related protein 3 Cripto-rel_3 Family

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Appella E Structure and function of epidermal growth factor-like regions in proteins. 1988 FEBS Lett 231 1-4
Doolittle RF Computer-based characterization of epidermal growth factor precursor. 1984 Nature 307 558-60
Davis CG The many faces of epidermal growth factor repeats. 1990 New Biol 2 410-9
Blomquist MC Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. 1984 Proc Natl Acad Sci U S A 81 7363-7
Hommel U Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha. 1992 J Mol Biol 227 271-82
Sorkin A Internalization of the epidermal growth factor receptor: role in signalling. 2001 Biochem Soc Trans 29 480-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)